SS-31
Large vials, milligram doses.
SS-31 is sold in some of the largest vials in this category, up to 50 mg, and dosed in milligrams. Both facts push the reconstitution volume in the same direction.
- Cost
- Free
- Syringe
- U-100
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- None
- Data
- Nothing stored
The science
Concentration when the vial is large
01
SS-31 is a synthetic peptide associated with mitochondrial membrane function. It is supplied as a lyophilised powder, and the vials are unusually large for this category: 10, 20 and 50 mg are all common presentations.
02
A large vial and a milligram-scale dose together set a narrow band of workable water volumes. Reconstitute 50 mg with 5 ml and you have 10 mg per ml, so a 5 mg dose is 0.5 ml, or 50 units. That sits comfortably in the middle of the barrel.
03
Move either variable and the margin disappears quickly. The same vial in 10 ml is 5 mg per ml, so that dose becomes a full 100 unit barrel, and most vials cannot hold 10 ml in any case. The physical capacity of the vial becomes a real constraint rather than a theoretical one.
04
The other half of the problem is time. A 50 mg vial holds ten doses of 5 mg, which at two injections a week is five weeks of solution. That is longer than most reconstituted peptide storage windows, so the vial size and the dosing frequency have to be considered together rather than separately.
Lookup
10, 20 and 50 mg vials at each water volume
A 50 mg vial holds ten doses of 5 mg. The table shows which water volumes keep those doses on a readable part of a 100 unit barrel and which overflow it.
10 mg SS-31 vial
Units on a U-100 syringe
| Dose | 1 ml | 1.5 ml | 2 ml | 2.5 ml | 3 ml |
|---|---|---|---|---|---|
| 2.5 mg | 25 | 37.5 | 50 | 62.5 | 75 |
| 5 mg | 50 | 75 | 100 | · | · |
| 10 mg | 100 | · | · | · | · |
20 mg SS-31 vial
Units on a U-100 syringe
| Dose | 1 ml | 1.5 ml | 2 ml | 2.5 ml | 3 ml |
|---|---|---|---|---|---|
| 2.5 mg | 12.5 | 18.75 | 25 | 31.25 | 37.5 |
| 5 mg | 25 | 37.5 | 50 | 62.5 | 75 |
| 10 mg | 50 | 75 | 100 | · | · |
| 20 mg | 100 | · | · | · | · |
50 mg SS-31 vial
Units on a U-100 syringe
| Dose | 1 ml | 1.5 ml | 2 ml | 2.5 ml | 3 ml |
|---|---|---|---|---|---|
| 2.5 mg | 5 | 7.5 | 10 | 12.5 | 15 |
| 5 mg | 10 | 15 | 20 | 25 | 30 |
| 10 mg | 20 | 30 | 40 | 50 | 60 |
| 20 mg | 40 | 60 | 80 | 100 | · |
A dot marks a combination that falls under two units or overflows a 100-unit barrel. Both are hard to measure accurately, so they are worth avoiding rather than eyeballing.
Regulatory status
SS-31 has not been approved
SS-31, also known as elamipretide, has been studied in clinical trials but has not been approved for human use by the FDA or any comparable regulator. No prescribing information exists and no regulator has published a dose.
It is covered by the World Anti-Doping Agency's S0 category, which captures any pharmacological substance with no current approval from any governmental health authority, so it is prohibited in tested sport at all times.
Material sold as SS-31 for research use carries no assurance of identity, purity or quantity, which matters here because the arithmetic assumes the milligram figure on the label is true. Careful division does not fix a wrong starting number.
FAQ
Common questions
How many units is 5 mg of SS-31?
From a 50 mg vial reconstituted with 5 ml, the concentration is 10 mg per ml, so 5 mg is 0.5 ml, which is 50 units on a U-100 syringe. From a 10 mg vial in 2 ml, the concentration is 5 mg per ml and the same dose is 100 units, the whole barrel. Record the water volume alongside any units figure.
How much bacteriostatic water for a 50 mg SS-31 vial?
Enough to dissolve it and no more than the vial can physically hold. Five millilitres gives 10 mg per ml, which keeps milligram-scale doses inside a single barrel. Larger volumes quickly exceed both the syringe capacity and the headroom in the vial.
Is SS-31 the same as elamipretide?
They refer to the same peptide sequence. Elamipretide is the name used in clinical development, and material sold as SS-31 for research use is not the same product as anything supplied through a trial. Nothing about the name changes the reconstitution arithmetic.
Is SS-31 approved?
No. It has not been approved for human use by the FDA or any comparable regulator. It has been studied in clinical trials under the name elamipretide, but being investigated is not the same as being approved, and there is no label or official dose to consult.
Will a 50 mg vial last long enough to use up?
That depends on your dose and frequency, and it is worth working out before reconstituting. Ten doses of 5 mg at two per week is five weeks, which exceeds most storage windows for a reconstituted solution. The vial expiry calculator on this site converts a window into a dose count so the mismatch is visible before you mix.
Sources
Where this comes from
Regulatory status and approved dosing are quoted from the primary source rather than summarised from memory. Each link below says what it is being cited for.
- Drugs@FDA: FDA-Approved DrugsU.S. Food and Drug AdministrationApproval status and approval history for any drug marketed in the United States.Link checked 1 October 2026
- The Prohibited ListWorld Anti-Doping AgencyThe current list of substances prohibited in tested sport, including peptide hormones and growth factors.Link checked 1 October 2026
- Bulk Drug Substances Used in Compounding Under Section 503A of the FD&C ActU.S. Food and Drug AdministrationThe three-category framework FDA applies to substances nominated for pharmacy compounding.Link checked 1 October 2026
VialClock
This page calculates. Your notes app forgets.
Every tool here is stateless by design. What it cannot do is remember that your vial was mixed eleven days ago, or that a step-up is due this week.
This tool performs arithmetic on figures you enter, or presents a manufacturer-published schedule. It does not know your protocol, will never suggest a dose, and is not medical advice. Dosing decisions belong with a qualified prescriber.